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vintafolide

Known as: Folate-Vinca Alkaloid Conjugate EC145 
A water-soluble, folate-receptor-targeted conjugate of folate and the vinca alkaloid desacetylvinblastine monohydrazide (DAVLBH) with potential… 
National Institutes of Health

Related topics

Related topics

6 relations
EC145Microtubule ProcessNCIt Antineoplastic Agent TerminologyNegative Regulation of Cell Cycle

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A phase 1 dose-escalation study of the folic acid-tubulysin small molecule drug conjugate (SMDC) folate-tubulysin EC1456 in advanced cancer patients.
2585Background: The folate receptor (FR) is highly expressed in several epithelial cancers (e.g. ovarian, NSCLC) but is expressed… 
2014
2014
Rational Combination Therapy of Vintafolide (EC145) with Commonly Used Chemotherapeutic Drugs
Purpose: When evaluated in patients with ovarian and other cancer, vintafolide (EC145), a potent folate-targeted vinca alkaloid… 
2014
2014
Abstract 832: Pre-clinical development of EC1456: A potent Folate targeted Tubulysin SMDC
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Folate targeted small molecule drug conjugates (SMDC) have… 
2014
2014
A New Generation of Cell-Targeted Drugs for Cancer Treatment
2014
2014
Abstract 1677: Preclinical activity of Vintafolide/MK-8109 monotherapy and in combination with standard of care therapy in triple-negative breast cancer models
Vintafolide (also known as EC145 or MK-8109), is a small molecule drug conjugate for the treatment of cancers expressing high… 
2013
2013
Gynaecological cancer: Vintafolide—targeting the folate receptor with a cytotoxic offers hope
Gynaecological cancer: Vintafolide—targeting the folate receptor with a cytotoxic offers hope 
2013
2013
Abstract 5502: Vintafolide: a first-in-class small molecule drug conjugate targeting folate receptor positive tumors.
Targeted anti-cancer therapies offer the promise of more efficacious treatments with fewer side effects. Vintafolide (also known… 
2013
2013
Abstract OT2-6-15: Efficacy and safety of vintafolide alone and vintafolide plus paclitaxel vs paclitaxel alone in advanced triple negative breast cancer subjects using etarfolatide subject selection
Background: Vintafolide (V) is a folic acid-vinca alkaloid small molecule drug conjugate that targets tumors that over-express… 
2012
2012
Biotech weathers 2Q12 slump
2003
2003
Flight Testing of the Eurocopter EC145
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