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sulforafan

Known as: sulforaphane, (R)-, 1-isothiocyanato-4-methylsulfinyl-butane, 1-isothiocyanato-4-methylsulphinylbutane 
A naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Anticarcinogenic AgentsIsothiocyanates

Papers overview

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Highly Cited
2012
Highly Cited
2012
Biotransformation of the Antiretroviral Drug Etravirine: Metabolite Identification, Reaction Phenotyping, and Characterization of Autoinduction of Cytochrome P450-Dependent Metabolism
Etravirine (ETR) is a second-generation non-nucleoside reverse transcriptase inhibitor prescribed for the treatment of HIV-1. By… 
Review
2010
Review
2010
Mouse models for unraveling the importance of diet in colon cancer prevention.
Highly Cited
2008
Highly Cited
2008
Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists
Very few antagonists have been identified for the human pregnane X receptor (PXR). These molecules may be of use for modulating… 
Highly Cited
2006
Highly Cited
2006
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells.
The cytotoxic effect of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is limited in some cancer cells… 
Highly Cited
2006
Highly Cited
2006
Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis
Sulforaphane (SUL), one of the isothiocyanates (ITCs), has recently been focused due to its inhibitory effects on tumor cell… 
Highly Cited
2006
Highly Cited
2006
Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.
Sulforaphane (SFN), a naturally occurring isothiocyanate, is an attractive agent because of its potent anticancer effects. SFN… 
Highly Cited
2004
Highly Cited
2004
Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables.
Highly Cited
2003
Highly Cited
2003
Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.
Thioredoxin reductases (TrxRs) catalyse the NADPH-dependent reduction of thioredoxin and play an important role in multiple… 
Highly Cited
2003
Highly Cited
2003
Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.
Highly Cited
2002
Highly Cited
2002
Effect of Organic Isothiocyanates on the P-Glycoprotein- and MRP1-Mediated Transport of Daunomycin and Vinblastine
AbstractPurpose. Organic isothiocyanates (ITCs), or mustard oils, are non-nutrient components present in the diet, especially in… 
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