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protein kinase C iota
Known as:
Atypical protein kinase C iota
, PKC iota
, protein kinase C-iota
National Institutes of Health
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Related topics
Related topics
2 relations
PRKCI gene
Broader (1)
protein kinase C lambda
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Targeting atypical protein kinase C iota reduces viability in glioblastoma stem‐like cells via a notch signaling mechanism
Emma Phillips
,
Verena Lang
,
+7 authors
V. Goidts
International Journal of Cancer
2016
Corpus ID: 3290497
In a previous study, Protein Kinase C iota (PRKCI) emerged as an important candidate gene for glioblastoma (GBM) stem‐like cell…
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2014
2014
Expression of PKC iota affects neuronal differentiation of PC12 cells at least partly independent of kinase function.
Alana Doonachar
,
A. Schoenfeld
CellBio
2014
Corpus ID: 16980334
Atypical PKC (aPKC) plays a role in establishing cell polarity and has been indicated in neuronal differentiation and…
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2012
2012
Abstract 446: Protein kinase Ciota is a new prognostic factor in gastric cancer
H. Kashihara
2012
Corpus ID: 70426310
Background: Protein kinase Ciota (PKCiota) have been reported to be an important effector of oncogenic K-ras. Furthermore…
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Highly Cited
2010
Highly Cited
2010
Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis.
M. L. Scotti
,
W. Bamlet
,
T. Smyrk
,
A. Fields
,
N. Murray
Cancer Research
2010
Corpus ID: 22697650
Pancreatic cancer is the fourth leading cause of cancer deaths in the United States, with an overall 5-year survival rate of <5…
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2009
2009
Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1)
W. Guo
,
Shuhong Wu
,
+4 authors
B. Fang
Molecular Cancer Therapeutics
2009
Corpus ID: 9218647
Protein kinase Cι (PKCι) is activated by oncogenic Ras proteins and is required for K-Ras–induced transformation and colonic…
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Highly Cited
2008
Highly Cited
2008
Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7.
B. Fiedler
,
Min-min Zhang
,
+5 authors
D. Yoshikami
Biochemical Pharmacology
2008
Corpus ID: 34241277
Highly Cited
2008
Highly Cited
2008
Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
W. Guo
,
Shuhong Wu
,
Jinsong Liu
,
B. Fang
Cancer Research
2008
Corpus ID: 2970927
K-Ras mutations are frequently found in various cancers and are associated with resistance to treatment or poor prognosis…
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2004
2004
Regulation of Interleukin Receptor-associated Kinase (IRAK) Phosphorylation and Signaling by Iota Protein Kinase C*
Vidya Mamidipudi
,
Chun-Tai Lin
,
M. Seibenhener
,
M. W. Wooten
Journal of Biological Chemistry
2004
Corpus ID: 12401014
We have previously shown that the activity of the interleukin-1 (IL-1) receptor-associated kinase (IRAK) is required for nerve…
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2004
2004
Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.
W. Gustafson
,
Sutapa Ray
,
L. Jamieson
,
E. Thompson
,
A. Brasier
,
A. Fields
Journal of Biological Chemistry
2004
Corpus ID: 22733742
The protein kinase C (PKC) family of serine/threonine kinases plays an important role in numerous cancer signaling pathways…
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Highly Cited
1999
Highly Cited
1999
Expression and translocation of protein kinase C isoforms in rat microglial and astroglial cultures
N. Slepko
,
M. Patrizio
,
G. Levi
Journal of Neuroscience Research
1999
Corpus ID: 35629727
Cellular distribution and activation by phorbol myristate acetate (PMA) of classical (α, βI, βII,γ), novel (δ, ϵ, θ, η), and…
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