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enalkiren
Known as:
(Alpha-S)-Alpha-((Alpha-S)-Alpha-(3-Amino-3-Methylbutyramido)-p-Methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(Cyclohexylmethyl)-2,3-Dihydroxy-5-Methylhexyl)Imidazole-4-Propionamide
, (N-(3-amino-3-methyl-1-oxobutyl)-4-methoxy-L-phenylalanyl)-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-L-histidinamide
, L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R*,2S*,3R*))-
National Institutes of Health
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Related topics
Related topics
3 relations
Narrower (1)
A 64662
Broader (2)
Dipeptides
Protease Inhibitors
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1995
1995
Renal vascular responses to renin inhibition with zankiren in men
N. Fisher
,
Norman H. Hollenberg
Clinical pharmacology and therapy
1995
Corpus ID: 8696291
1993
1993
Simultaneous Modeling of the Pharmacokinetic and Pharmacodynamic Properties of Enalkiren (Abbott‐64662, A Renin Inhibitor). II: A Dose‐Ranging Study in Patients with Congestive Heart Failure
S. K. Gupta
,
G. Granneman
,
M. Packer
,
R. Boger
Journal of Cardiovascular Pharmacology
1993
Corpus ID: 41918972
This study describes the relationship between the measured effects (the acute effects on systemic hemodynamics and cardiac…
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1992
1992
C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties.
S. Boyd
,
A. Fung
,
+7 authors
V. Klinghofer
Journal of Medicinal Chemistry
1992
Corpus ID: 32560209
We describe the development of a series of soluble, potent, and bioavailable nonpeptide renin inhibitors. These inhibitors…
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1992
1992
Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of enalkiren (Abbott-64662, a new renin inhibitor). I: Single dose study.
S. Gupta
,
G. Granneman
,
R. Boger
,
N. Hollenberg
,
R. Luther
Drug Metabolism And Disposition
1992
Corpus ID: 24391401
This study describes the relationship between the measured effects (angiotensin I and renal plasma flow) and plasma drug levels…
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1990
1990
Synthesis of polypeptides by microwave heating II. Function of polypeptides synthesized during repeated hydration-dehydration cycles
Masahiko Ito
,
N. Handa
,
H. Yanagawa
Journal of Molecular Evolution
1990
Corpus ID: 45975236
SummaryPolypeptides, synthesized from a mixture of amino acid amides by microwave heating during repeated hydration-dehydration…
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Review
1990
Review
1990
Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor.
H. Glassman
,
H. Kleinert
,
R. Boger
,
D. Moyse
,
A. Griffiths
,
R. Luther
Journal of Cardiovascular Pharmacology
1990
Corpus ID: 31383514
Enalkiren (A-64662), a potent, dipeptide renin inhibitor, mimics the transition state of the human renin substrate…
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1990
1990
Effects of renin inhibition in systemic hypertension.
P. W. Anderson
,
Y. Do
,
+4 authors
W. Hsueh
American Journal of Cardiology
1990
Corpus ID: 21524462
1990
1990
Prolonged Duration of Blood Pressure Response to Enalkiren, the Novel Dipeptide Renin Inhibitor, in Essential Hypertension
R. Boger
,
H. Glassman
,
+6 authors
R. Luther
HYPERTENSION
1990
Corpus ID: 487458
The effects of sustained renin inhibition by repeated administration of enalkiren (A- 64662), the novel dipeptide renin inhibitor…
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1990
1990
Assessment of renin dependency of hypertension with a dipeptide renin inhibitor.
M. Weber
,
J. Neutel
,
I. Essinger
,
H. Glassman
,
R. Boger
,
R. Luther
Circulation
1990
Corpus ID: 6642092
To evaluate the participation of the renin-angiotensin system in sustaining hypertension, we administered the specific dipeptide…
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Highly Cited
1989
Highly Cited
1989
Hemodynamic and Humoral Effects of the New Renin Inhibitor Enalkiren in Normal Humans
A. Delabays
,
Jiirg Nussberger
,
+7 authors
H. Brunner
HYPERTENSION
1989
Corpus ID: 22845782
The effect of the renin inhibitor enalkiren (Abbott- 64662) was evaluated in eight normal volunteer subjects on a standardized…
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