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RUNX1T1 gene
Known as:
ETO
, RUNX1T1
, RUNX1, TRANSLOCATED TO, 1
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This gene plays a role in transcriptional regulation and hematopoiesis.
National Institutes of Health
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Related topics
Related topics
7 relations
AML1-ETO Fusion Protein Expression
CBFA2T1 protein, human
Homo sapiens
Transcriptional Regulation
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Broader (1)
Genes
Narrower (1)
RUNX1T1 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy.
A. Boyapati
,
Ming Yan
,
L. Peterson
,
J. Biggs
,
M. L. Le Beau
,
Dong-er Zhang
Blood
2007
Corpus ID: 12514917
The 8;21 chromosomal translocation occurs in 15% to 40% of patients with the FAB M2 subtype of acute myeloid leukemia (AML). This…
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2007
2007
Expression of AML/Runx and ETO/MTG family members during hematopoietic differentiation of embryonic stem cells.
A. Okumura
,
L. Peterson
,
Miao-Chia Lo
,
Dong-er Zhang
Experimental Hematology
2007
Corpus ID: 41970476
2004
2004
Complex translocation (8;12;21): a new variant of t(8;21) in acute myeloid leukemia.
C. Farra
,
J. Awwad
,
A. Valent
,
F. Lozach
,
A. Bernheim
Cancer Genetics and Cytogenetics
2004
Corpus ID: 23725885
Highly Cited
2001
Highly Cited
2001
MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes
T. Fukuyama
,
E. Sueoka
,
+4 authors
T. Kozu
Oncogene
2001
Corpus ID: 34697182
AML1-MTG8 chimeric oncogene is generated in acute myelogenous leukemia with t(8;21), and seems to be responsible for the…
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Highly Cited
1999
Highly Cited
1999
ETO-2, a new member of the ETO-family of nuclear proteins
Davis Jn
,
Williams Bj
,
Herron Jt
,
Galiano Fj
,
S. Meyers
Oncogene
1999
Corpus ID: 25931396
The t(8;21) is associated with 12 – 15% of acute myelogenous leukemias of the M2 subtype. The translocation results in the fusion…
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1999
1999
Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2
H. Kohzaki
,
Kosei Ito
,
Gang Huang
,
Heejun Wee
,
Y. Murakami
,
Yoshiaki Ito
Oncogene
1999
Corpus ID: 8704857
The chimeric gene, AML1/ETO (MTG8), generated in t(8;21) acute myeloid leukemia enhances the expression of Bcl-2. To evaluate…
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1998
1998
Characterization of the ETO and AML1–ETO proteins involved in the 8;21 translocation in acute myelogenous leukemia
X. Le
,
D. Claxton
,
S. Kornblau
,
Youhong Fan
,
Z. Mu
,
K. Chang
European Journal of Haematology
1998
Corpus ID: 8982870
Abstract: The AML1 and ETO genes are disrupted by the nonrandom chromosomal translocation t(8;21) in acute myelogenous leukemia…
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Review
1997
Review
1997
The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias.
F. Coco
,
Simona Pisegna
,
D. Diverio
Haematologica
1997
Corpus ID: 26361065
BACKGROUND AND OBJECTIVE The AML1 gene was identified in 1991 by cloning the t(8;21) chromosome translocation associated with FAB…
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1995
1995
Identification of two transcripts of AMLI/ETO‐fused gene in t(8;21) leukemic cells and expression of wild‐type ETO gene in hematopoietic cells
T. Era
,
N. Asou
,
+6 authors
K. Takatsuki
Genes, Chromosomes and Cancer
1995
Corpus ID: 41918020
The t(8; 21) is a common chromosomal abnormality, preferentially associated with acute leukemia showing features of myeloid…
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1994
1994
Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2.
J. Tighe
,
F. Calabi
Blood
1994
Corpus ID: 6403597
In the t(8;21) of acute myeloid leukemia (AML) M2, breakpoints are clustered on both chromosomes. The chromosome 21 breakpoint…
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