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PKI 166
Known as:
PKI-166
, PKI166
A pyrrolo-pyrimidine epidermal growth factor receptor (EGFR) protein kinase inhibitor with anti-tumor activity.PKI-166 reversibly inhibits HER1 and…
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National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Pyrimidines
Pyrroles
Receptor Tyrosine Kinase Inhibition
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase
S. Forsberg
,
A. Östman
,
O. Rollman
Archives of Dermatological Research
2008
Corpus ID: 8537904
The family of human epidermal growth factor receptors (EGFR, HER2–4) exerts key functions in normal and malignant epithelial…
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Highly Cited
2004
Highly Cited
2004
Simultaneous Blockade of Platelet-Derived Growth Factor-Receptor and Epidermal Growth Factor-Receptor Signaling and Systemic Administration of Paclitaxel as Therapy for Human Prostate Cancer…
S. J. Kim
,
H. Uehara
,
+6 authors
I. Fidler
Cancer Research
2004
Corpus ID: 9967094
Once prostate cancer metastasizes to bone, conventional chemotherapy is largely ineffective. We hypothesized that inhibition of…
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Highly Cited
2004
Highly Cited
2004
Cooperation between Fibroblast Growth Factor Receptor-4 and ErbB2 in Regulation of Cyclin D1 Translation*
M. Koziczak
,
N. Hynes
Journal of Biological Chemistry
2004
Corpus ID: 21342791
Alterations in ErbB2 or fibroblast growth factor receptor-4 (FGFR-4) expression and activity occur in a significant fraction of…
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2004
2004
HEPATIC TRANSPORT OF PKI166, AN EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR OF THE PYRROLO-PYRIMIDINE CLASS, AND ITS MAIN METABOLITE, ACU154
T. Takada
,
H. Weiss
,
O. Kretz
,
G. Gross
,
Y. Sugiyama
Drug Metabolism And Disposition
2004
Corpus ID: 39298210
PKI166, a specific inhibitor of the tyrosine kinase activity of two epidermal growth factor receptors, was under development for…
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2004
2004
Long-term presence of androgens and anti-androgens modulate EGF-receptor expression and MAP-kinase phosphorylation in androgen receptor-prostate positive cancer cells.
G. Gravina
,
C. Festuccia
,
+5 authors
M. Bologna
International Journal of Oncology
2004
Corpus ID: 44785508
Prostate cancer (Pca) progression from an androgen-dependent to an androgen-independent state occurs in patients who undergo…
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2003
2003
Skin as a surrogate tissue for pharmacodynamic end points: is it deep enough?
J. Baselga
Clinical Cancer Research
2003
Corpus ID: 18046895
As the number of molecular-targeted agents under clinical development keeps growing, it is becoming increasingly evident that it…
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Highly Cited
2003
Highly Cited
2003
Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate cancer growing in the bone of nude mice…
Sun-jin Kim
,
H. Uehara
,
T. Karashima
,
D. Shepherd
,
J. Killion
,
I. Fidler
Clinical Cancer Research
2003
Corpus ID: 13051545
PURPOSE We determined whether blockade of the epidermal growth factor receptor (EGF-R) signaling pathway by oral administration…
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Highly Cited
2003
Highly Cited
2003
Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.
K. Weber
,
M. Doucet
,
J. Price
,
C. Baker
,
S. J. Kim
,
I. Fidler
Cancer Research
2003
Corpus ID: 14722886
Renal cell carcinoma (RCC) frequently produces metastases to the musculoskeletal system that are a major source of morbidity in…
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Highly Cited
2002
Highly Cited
2002
Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice.
D. Kedar
,
C. Baker
,
J. Killion
,
C. Dinney
,
I. Fidler
Clinical Cancer Research
2002
Corpus ID: 36287809
We determined whether blockade of the epidermal growth factor-receptor (EGF-R) signaling pathway by oral administration of the…
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Highly Cited
1990
Highly Cited
1990
Specificities of autoinhibitory domain peptides for four protein kinases. Implications for intact cell studies of protein kinase function.
M. Smith
,
R. Colbran
,
T. Soderling
Journal of Biological Chemistry
1990
Corpus ID: 13123549
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