MLN3897
National Institutes of Health
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MLN3897 is a small molecule antagonist of the C-C chemokine receptor-1. Since preclinical studies showed that the…
A novel in vitro model was recently developed in our laboratories for the prediction of magnitude of clinical pharmacokinetic…
Osteolytic lesions are a hallmark of myeloma bone disease and other metastatic cancers, resulting in significant morbidity. In…
Multiple Myeloma (MM) is characterized by increased osteoclasts (OC) activity leading to severe bone disease. Several inducers of…