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MK 499
Known as:
MK-499
National Institutes of Health
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1 relation
L 706000
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.
Q. Deng
,
Yeon-Hee Lim
,
+14 authors
Amjad Ali
Bioorganic & Medicinal Chemistry Letters
2015
Corpus ID: 20464878
Highly Cited
2005
Highly Cited
2005
QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals.
S. Toyoshima
,
Akihiro Kanno
,
+7 authors
Keiji Yamamoto
Journal of Pharmacological Sciences
2005
Corpus ID: 7593095
The goal of the present study was to examine the utility of the conscious dog model by assessing the QT-interval-prolonging…
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Review
2005
Review
2005
Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs.
M. Sanguinetti
,
Jun Chen
,
David Fernandez
,
K. Kamiya
,
J. Mitcheson
,
J. Sánchez-Chapula
Novartis Foundation symposium
2005
Corpus ID: 26180600
Blockade of hERG K+ channels in the heart is an unintentional side effect of many drugs and can induce cardiac arrhythmia and…
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2005
2005
A pH‐sensitive potassium conductance (TASK) and its function in the murine gastrointestinal tract
Sang Yun Cho
,
E. Beckett
,
+6 authors
S. D. Koh
Journal of Physiology
2005
Corpus ID: 38230432
The excitability of smooth muscles is regulated, in part, by background K+ conductances that determine resting membrane potential…
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2002
2002
Potassium Channel Antagonists Influence Porcine Granulosa Cell Proliferation, Differentiation, and Apoptosis1
M. Manikkam
,
Yan Li
,
B. M. Mitchell
,
D. Mason
,
L. Freeman
Biology of Reproduction
2002
Corpus ID: 19802044
Abstract This investigation determined the effects of K+ channel antagonists on proliferation, differentiation, and apoptosis of…
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1998
1998
Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs.
S. Vickers
,
C. Duncan
,
+4 authors
K. Vyas
Drug Metabolism And Disposition
1998
Corpus ID: 38380359
MK-499 [(+)-N-[1'-(6-cyano-1, 2, 3, 4-tetrahydro-2(R)-naphthalenyl)-3, 4-dihydro-4(R)-hydroxyspiro(2H-1-benzopyran-2, 4…
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1996
1996
Differential efficacy of the class III agent MK-499 against programmed stimulation-induced and ischemic-induced ventricular arrhythmias in a canine model of previous myocardial infarction.
J. Lynch
,
A. Wallace
,
G. Stump
,
R. Stupienski
,
T. Kothstein
,
J. Gehret
Journal of Pharmacology and Experimental…
1996
Corpus ID: 29819585
Class III activity has been proposed as a potential mechanism for the treatment of reentrant arrhythmias. The purpose of the…
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Highly Cited
1994
Highly Cited
1994
Cardiac electrophysiologic and antiarrhythmic actions of two long-acting spirobenzopyran piperidine class III agents, L-702,958 and L-706,000 [MK-499].
J. Lynch
,
A. Wallace
,
+7 authors
R. Stein
Journal of Pharmacology and Experimental…
1994
Corpus ID: 29587479
The cardiac electrophysiologic and antiarrhythmic actions of two Class III ketone- and alcohol-containing spirobenzopyran…
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Review
1994
Review
1994
Class III antiarrhythmic drugs.
Bramah INI. Singh
,
R. Ahmed
Current Opinion in Cardiology
1994
Corpus ID: 23958139
Pharmacological therapy of cardiac arrhythmias continues to evolve, with an increasing shift from class I to class III compounds…
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Highly Cited
1994
Highly Cited
1994
Potassium channel blockers as antiarrhythmic drugs
T. Colatsky
,
T. Argentieri
1994
Corpus ID: 74688095
Selective prolongation of cardiac repolarization is an effective means of suppressing a variety of cardiac arrhythmias…
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