Skip to search formSkip to main contentSkip to account menu

DNA Topoisomerase IV

Known as: Topoisomerase IV, DNA, Topo IV, DNA Topoisomerase IV [Chemical/Ingredient] 
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks… 
National Institutes of Health

Related topics

Related topics

14 relations
BacteriaDNA ReplicationDNA Topology RegulationDNA topoisomerase type II activity

Narrower (2)

parC ProteinparE Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases.
2006
2006
The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase.
2004
2004
Replacement of ParC α4 Helix with That of GyrA Increases the Stability and Cytotoxicity of Topoisomerase IV-Quinolone-DNA Ternary Complexes
ABSTRACT Replacement of the α4 helix of ParC with that of GyrA increased the stability of topoisomerase IV-quinolone-DNA ternary… 
2002
2002
Computational analysis of the chiral action of type II DNA topoisomerases.
Highly Cited
2000
Highly Cited
2000
Potent Antipneumococcal Activity of Gemifloxacin Is Associated with Dual Targeting of Gyrase and Topoisomerase IV, an In Vivo Target Preference for Gyrase, and Enhanced Stabilization of Cleavable…
ABSTRACT We investigated the roles of DNA gyrase and topoisomerase IV in determining the susceptibility of Streptococcus… 
Highly Cited
1999
Highly Cited
1999
Activities of Fluoroquinolones againstStreptococcus pneumoniae Type II Topoisomerases Purified as Recombinant Proteins
ABSTRACT Streptococcus pneumoniae topoisomerase IV and DNA gyrase have been purified from a fluoroquinolone… 
Highly Cited
1996
Highly Cited
1996
Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro
The MICs of trovafloxacin, ciprofloxacin, ofloxacin, and sparfloxacin at which 90% of isolates are inhibited for 55 isolates of… 
Highly Cited
1996
Highly Cited
1996
The probabilities of supercoil removal and decatenation by yeast DNA topoisomerase II
Background:  In yeast a single type II DNA topoisomerase is involved in both the removal of DNA supercoils and the unlinking of… 
1995
1995
A general genetic approach in Escherichia coli for determining the mechanism(s) of action of tumoricidal agents: application to DMP 840, a tumoricidal agent.
We describe here a simple and easily manipulatable Escherichia coli-based genetic system that permits us to identify bacterial… 
Highly Cited
1994
Highly Cited
1994
Escherichia coli tyrT gene transcription is sensitive to DNA supercoiling in its native chromosomal context: effect of DNA topoisomerase IV overexpression on tyrT promoter function
We have investigated the in vivo DNA supercoiling sensitivity of the Escherichia coli tRNAtyr1 gene (tyrT) promoter in its normal… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)