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5-hydroxyprimaquine
Known as:
5-HPQ
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Primaquine
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Methemoglobin generation by 8-aminoquinolines: effect of substitution at 5-position of primaquine.
Haining Liu
,
B. Tekwani
,
N. Nanayakkara
,
L. Walker
,
R. J. Doerksen
Chemical Research in Toxicology
2013
Corpus ID: 41081736
Currently, the only clinically approved antimalarial drug to treat relapsing malaria is primaquine (PQ), yet PQ administration…
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2011
2011
Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase.
Haining Liu
,
L. Walker
,
N. Nanayakkara
,
R. J. Doerksen
Journal of the American Chemical Society
2011
Corpus ID: 207058876
We suggest a possible mechanism of how 8-aminoquinolines (8-AQ's) cause hemotoxicity by oxidizing hemoglobin to methemoglobin. In…
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2005
2005
Primaquine-Induced Hemolytic Anemia: Role of Membrane Lipid Peroxidation and Cytoskeletal Protein Alterations in the Hemotoxicity of 5-Hydroxyprimaquine
Z. Bowman
,
J. Morrow
,
D. Jollow
,
D. McMillan
Journal of Pharmacology and Experimental…
2005
Corpus ID: 7406971
Primaquine-induced hemolytic anemia is a toxic side effect that is due to premature splenic sequestration of intact erythrocytes…
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1996
1996
High-performance liquid chromatographic determination of primaquine and carboxyprimaquine concentrations in plasma and blood cells in Plasmodium vivax malaria cases following chronic dosage with…
V. Dua
,
P. K. Kar
,
R. Sarin
,
V. Sharma
Journal of chromatography. B, Biomedical…
1996
Corpus ID: 28108671
1995
1995
Side-chain hydroxylation in the metabolism of 8-aminoquinoline antiparasitic agents.
O. R. Idowu
,
J. Peggins
,
T. Brewer
Drug Metabolism And Disposition
1995
Corpus ID: 27505185
Primaquine, 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline, is an antimalarial 8-aminoquinoline derivative. Although it has…
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1991
1991
Susceptibility of glucose-6-phosphate dehydrogenase deficient red cells to primaquine, primaquine enantiomers, and its two putative metabolites. II. Effect on red blood cell membrane, lipid…
S. Agarwal
,
U. Gupta
,
C. Daniel
,
R. Gupta
,
N. Anand
,
S. Agarwal
Biochemical Pharmacology
1991
Corpus ID: 30716204
1990
1990
ESR detection of free radical intermediates during autoxidation of 5-hydroxyprimaquine.
J. Vasquez-Vivar
,
O. Augusto
Free Radical Research Communications
1990
Corpus ID: 31359862
Autoxidation of 5-hydroxyprimaquine, a putative metabolite of the antimalarial primaquine, was studied by oxygen consumption and…
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1987
1987
Photooxidation products of primaquine Structure, antimalarial activity and hemolytic effects
A. Brossi
,
Wieslaw Gessner
,
+4 authors
I. Landau
FEBS Letters
1987
Corpus ID: 34091460
1986
1986
Characterization of the Urinary Metabolites of Primaquine in Rats
J. K. Baker
,
J. McChesney
,
L. Jorge
Pharmaceutical Research
1986
Corpus ID: 23378772
Following the synthesis of reference standards of the primaquine metabolites, a high-performance liquid chromatographic (HPLC…
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1985
1985
Structure-activity relationships of putative primaquine metabolites causing methemoglobin formation in canine hemolysates.
C. M. Link
,
A. Theoharides
,
J. Anders
,
H. Chung
,
C. Canfield
Toxicology and Applied Pharmacology
1985
Corpus ID: 2037014
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