The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients.
@article{Pooya2010TheEO, title={The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients.}, author={Shabnam Pooya and Mahmood Jalali and A Jazayery and Ahmad Saedisomeolia and Mohammad Reza Eshraghian and Fatemeh Toorang}, journal={Nutrition, metabolism, and cardiovascular diseases : NMCD}, year={2010}, volume={20 5}, pages={ 326-31 }, url={https://api.semanticscholar.org/CorpusID:885073} }
62 Citations
Effects of Omega-3 Fatty Acids Supplement on Antioxidant Enzymes Activity in Type 2 Diabetic Patients
- 2016
Medicine
Daily supplementation of 2714 mg mega-3 for two mo results in a significant reduction in HbA1c level in type2 diabetic patients with no effects on antioxidant enzymes activity.
Effects of Pure Eicosapentaenoic and Docosahexaenoic Acids on Oxidative Stress, Inflammation and Body Fat Mass in Patients with Type 2 Diabetes
- 2013
Medicine
This report is the first report demonstrating that neither EPA nor DHA have effects on body fat mass in type 2 diabetic patients, and prevent increasing oxidative stress without changing marker of inflammation.
Efficacy of omega-3 fatty acid supplementation on serum levels of tumour necrosis factor-alpha, C-reactive protein and interleukin-2 in type 2 diabetes mellitus patients.
- 2012
Medicine
Short-term omega-3 fatty acid supplementation (3 g/day for eight weeks) can decrease the serum levels of TNF-α and IL-2 in diabetic patients, with no change in CRP levels.
Biological Effects of Add-On Eicosapentaenoic Acid Supplementation in Diabetes Mellitus and Co-Morbid Depression: A Randomized Controlled Trial
- 2012
Biology, Medicine
Overall, add-on EPA-supplementation had limited effects on biological risk factors for adverse outcome in this sample of DM-patients with comorbid MDD.
Inflammatory biomarkers, antioxidant enzyme ac-tivities, and oxidative stress in Iranian male pa-tients with type 2 diabetes mellitus: Effects of ei-cosapentaenoic acid and vitamin C supplementa-tion
- 2012
Medicine, Environmental Science
It is concluded that eight weeks of EPA + vitamin C supplementation improved inflammation and antioxidant status in male type-2 diabetic patients.
Effects of Omega-3 Fatty Acid Supplementation on Glucose Control and Lipid Levels in Type 2 Diabetes: A Meta-Analysis
- 2015
Medicine
The ratio of EPA/DHA and early intervention with omega 3 fatty acids may affect their effects on glucose control and lipid levels, which may serve as a dietary reference for clinicians or nutritionists who manage diabetic patients.
Effect of JYTK on Antioxidant Status and Inflammation in Patients With Type 2 Diabetes: A Randomized Double-Blind Clinical Trial
- 2016
Environmental Science, Medicine
JYTK combined with metformin improves some antioxidant indices (SOD and MDA), and decreases inflammation in patients with T2DM, suggesting that it can reduce the risk of diabetic complications.
Association between Omega-3 Index and Hyperglycemia Depending on Body Mass Index among Adults in the United States
- 2022
Medicine
It is suggested that a low Omega-3 Index is associated with a greater risk of disordered glucose metabolism and this is independent of BMI.
Do B Vitamins Enhance the Effect of Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Diseases? A Systematic Review of Clinical Trials
- 2022
Medicine
The overall findings are inconsistent and inconclusive, yet the combined supplementation of these two nutrients may be more effective at reducing plasma homocysteine, triglyceride, and low-density lipoprotein-cholesterol than the individual components.
Treatment for 6 months with fish oil-derived n-3 polyunsaturated fatty acids has neutral effects on glycemic control but improves dyslipidemia in type 2 diabetic patients with abdominal obesity: a randomized, double-blind, placebo-controlled trial
- 2016
Medicine
It was showed that 6 months of fish oil supplement had no statistically significant effects on glycemic control, but improved TG and HDL-C in type 2 diabetic patients with abdominal obesity.
38 References
Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants.
- 1997
Medicine
Omega-3 FAs neither rendered the LDL particles more susceptible to undergo in vitro oxidation nor influenced mononuclear cells' ability to oxidize autologous LDL, whereas moderate amounts of antioxidants protected LDL against oxidative modification.
[Effect of n-3 polyunsaturated fatty acids on plasma lipid, LDL lipoperoxidation, homocysteine and inflammation indicators in diabetic dyslipidemia treated with statin + fibrate combination].
- 2005
Medicine
The results show that n-3 PUFA supplementation together with statin + fibrate combination in DDL patients can significantly decrease the risk of cardiovascular diseases.
Brief communication: omega-3 essential fatty acid supplementation and erythrocyte oxidant/antioxidant status in rats.
- 2005
Medicine
Omega-3 fatty acid supplementation helps to prevent lipid peroxidation and to safeguard erythrocytes from oxidative injury in rats, and might possibly protect tissues from oxygen free radical injury in the various diseases in which the oxidant/antioxidant defense mechanisms are disturbed.
Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review.
- 2006
Medicine
Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health.
- 2003
Medicine
This study reports for the first time the apparent interaction of n-3 fatty acids and nitric oxide on Hcy metabolism and changes in total Hcy and NO(x) plasma concentrations observed after 8 weeks of FO were found to be significantly correlated.
n-3 Fatty acids plus oleic acid and vitamin supplemented milk consumption reduces total and LDL cholesterol, homocysteine and levels of endothelial adhesion molecules in healthy humans.
- 2003
Agricultural and Food Sciences, Medicine
Daily intake of n -3 PUFA and oleic acid supplemented skimmed milk plus folic acid and B-type vitamins has favourable effects on risk factors for CVD.
A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats.
- 2001
Medicine
In hypertensive rats, GLA + EPA + DHA supplementation lowers blood pressure, enhances total anti-oxidant status and resistance to lipid peroxidation, diminishes platelet aggregation speed and lowers plasma lipid concentrations, which enhances protection against cardiovascular diseases.
n-3 Fatty Acids in the Treatment of Diabetic Patients Biological rationale and clinical data
- 2007
Medicine, Biology
The bulk of epidemiological data suggests the existence of favorable associations between fish consumption and mortality from CHD, and many properties ascribed to n-3 fatty acids appear to be particularly applicable to diabetic patients, where the need for “nontraditional” preventive or therapeutic measures is even higher than for cardiovascular disease in general.
Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women.
- 2004
Medicine, Agricultural and Food Sciences
It is suggested that dietary (n-3) fatty acids are associated with levels of these biomarkers reflecting lower levels of inflammation and endothelial activation, which might explain in part the effect of these fatty acids in preventing cardiovascular disease.